Sorafenib is a cancer treatment and is also known by its brand name, Nexavar.

Sorafenib is a targeted cancer drug and is also known by its brand name, Nexavar. It is a possible treatment for:

a type of liver cancer called hepatocellular

carcinomasome types of thyroid cancer when radioactive iodine treatment has not worked

How sorafenib works

Sorafenib is a type of targeted cancer drug called a cancer growth blocker. It works in two ways. It stops:

 signals that tell cancer cells to grow

cancer cells forming new blood vessels, which they need to be able to grow

Management of advanced hepatocellular carcinoma (HCC) is still a challenge to physicians since these patients are not candidates for surgical or ablative therapy. The disease carries a very poor prognosis with an expected survival of 4–6 months. No chemotherapeutic agent has been proven to improve the clinical outcome in such patients. A multikinase inhibitor, sorafenib, previously tested and found effective in other solid tumors recently found to significantly improve survival in patients with advanced HCC. Sorafenib exerts its action through inhibition of several kinases involved in both tumour cell proliferation and angiogenesis. It was well tolerated at a dose of 400 mg twice daily and permanent discontinuation of the drug was rarely required.

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